July 28, 2025 by Dahn Jeong (1), Stanley Wong (2), Mohammad Ehsanul Karim (1,3), Amee R. Manges (1,2), Jean Damascene Makuza (1), Héctor Alexander Velásquez García (1,2), Prince Asumadu Adu (1,2), Mawuena Binka (1,2), Amanda Yu (2), Sofia R. Bartlett (1,2), Mel Krajden (2,4), Naveed Zafar Janjua (1,2,3) Affiliations: 1. School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada 2. British Columbia Centre for Disease Control, Vancouver, BC, Canada 3. Centre for Advancing Health Outcomes, St. Paul's Hospital, Vancouver, BC, Canada 4. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada
Background and importance Hepatitis C virus (HCV) infection extends far beyond liver-related complications, triggering chronic systemic inflammation that leads to extrahepatic manifestations including type 2 diabetes, cardiovascular and cerebrovascular diseases, neurocognitive disorders, and kidney dysfunction. The majority of patients with chronic HCV infection develop one or more of these serious conditions, significantly impacting their long-term…
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